SYSE Bio-tech. Co., Ltd. is a professional company focusing on the research of laboratory animal metabolism. Please join us and contribute to the research of human diseases.



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PLX5622  and PLX5622-FA                                                           For Research use Olny-仅供科研使用,严禁用于人或动物的治疗等任何其他用途

PLX5622 or PLX5622FA (hemifumarate) is a highly selective brain penetrant and oral active inhibitor of CSF1R(Ki of 5.9 nM). PLX5622 or PLX5622-FA can eliminate microglia in the brain, which can persist in wild-type and Alzheimer's disease model mice (3xTg-AD model). In the AD model, PLX5622 or PLX5622-FA can prevent the association of microglia with amyloid beta plaques and improve cognitive ability. PLX5622-FA is the hemifumarate form of PLX5622 (PLX5622 Hemifumarate), which has more stable chemical properties.

PLX5622 & PLX5622-FA是一种高度选择性的,血脑屏障可渗透和具有口服活性的CSF1R抑制剂,其Ki值为5.9 nM。PLX5622可消除大脑中的小胶质细胞,这在野生型和阿尔茨海默氏病模型小鼠(3xTg-AD模型)中可以持续存在。在AD模型中,PLX5622 & PLX5622-FA防止小胶质细胞与淀粉样蛋白β斑块缔合,并改善了认知能力。PLX5622-FA 为PLX5622的半富马酸盐形式(PLX5622 Hemifumarate),具有更加稳定的化学特性。



PLX5622结构式



PLX5622 Purity: >98.00%

Molecular Formula-分子式:C₂₁H₁₉F₂N₅O

MW-分子量:395.41

Item No.-货号:JP-2112




PLX5622-FA     (PLX5622 Hemifumarate)    Purity: >98.00%

Molecular Formula-分子式:C₂₃H₂₁F₂N₅O₃

MW-分子量:453.54

Item No.-货号:JP-2113





Custom Diet with PLX5622 and Control Diet

Product #-货号:PD1001

Descrption-产品描述: AIN-76A  Control Diet

Specification-规格:500克/包, 500gm/bag

Form-形式:1/2“ pellet

Product #-货号:D20010802

Descrption-产品描述:Based on AIN-76A with 1380ppm PLX5622-FA

(Free base-有效含量:1200ppm PLX5622)。

Specification-规格:500克/包, 500gm/bag

Form-形式:1/2“ pellet

Product #-货号:D20010801

Description-产品描述:Based on AIN-76A with 1200ppm PLX5622

Specification-规格:500克/包, 500gm/bag

Form-形式:1/2“ pellet

Client's  literatures:

 

1.Rao Y., Du S., Yang B., Wang Y., Li Y., Li R., Zhou T., Du X., He Y., Wang Y., Zhou X., Yuan T.-F., Mao Y. and Peng B. (2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming, Neuron 109. 


2.Xu Z., Rao Y., Huang Y., Zhou T., Feng R., Xiong S., Yuan T.F., Qin S., Lu Y., Zhou X., Li X., Qin B., Mao Y., and Peng B. (2020) Efficient strategies for microglia replacement in the central nervous system. Cell Reports 32, 108041. 


3.Xu, Z., Zhou, X., Peng, B., and Rao, Y. (2021). Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice. STAR Protocols 2, 100666. 


4.Xu, Z., Rao, Y., and Peng, B. (2021). Protocol for microglia replacement by peripheral blood (Mr PB). STAR Protocols 2, 100613. 


5.Xu, Z., Peng, B., and Rao, Y. (2021). Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain. STAR Protocols 2, 100665.



Quality Commitment:


质量承诺:



The each batch of compounds pass the pre-experiment. 


The clearance rate of cortical microglia over 90% (WT mice) after 14-days treatment.


A full-refund or exchange is available for invalid experiments.


We provide above compounds and custom diets to many laboratories of the China Microcolloid Branch for long time. We have the  rich production experience and excellent quality control system. Worthy of your trust!


保证每批次产品通过预实验后再进行销售。


保证14天后皮层小胶质细胞清除率在90%以上(WT小鼠)。


实验无效可全额退款或换货。


我司常年为中国小胶质分会众多实验室提供此款合成产品,具有丰富的生产经验和优秀的质控体系。值得您的信任。